Publications

2025 Publications

Advanced rational design of polymeric nanoparticles for the controlled delivery of biologics.
Rodriguez-Cruz, J. J., Chapa-Villarreal, F. A., Duggal, I., NA Peppas. J. Contrilled Release. (2025).

Drug Delivery Technologies for the Treatment of Age-Related Macular Degeneration.
Rodriguez-Cruz, J. J., Cutrufello, J., Lam, M., Nallaparaju, S., NA Peppas. Advanced Science. (2025)

Designing the Next Generation of Biomaterials through Nanoengineering.
Davis Jr., R., Duggal, I., NA Peppas, & Gaharwar, A. K. Advanced Materials. (2025)

Rational design of stimuli responsive nanoparticle systems for the controlled, intracellular delivery of immunotherapeutic and chemotherapeutic agents.
Huang, D., Duggal, I., Matthews, B. C., Lee, E., Tong, E., NA Peppas (2025).

Rational Design of PEGylated Nanogels: Optimization of Degree of PEGylation and Development of a Novel Enzyme-Responsive Grafted Layer.
Wagner, A. M., Duggal, I., Morse, B., Lawrence, A., Shearer, A., Al-Sayyad, N., NA Peppas. Int. J. of Pharmaceutics. (2025).

Polybasic nanogels for intracellular co-delivery of paclitaxel and carboplatin: A novel approach to ovarian cancer therapy.
M. Wagner, A., L. Lanier, O., Savk, A., NA Peppas. RSC pharmaceutics (2025).

2024 Publications

The role of patient-specific variables in protein corona formation and therapeutic efficacy in nanomedicine.
Cisneros, E. P., Morse, B. A., Savk, A., Malik, K., NA Peppas, & Lanier, O. L. Journal of Nanobiotechnology (2024).

Paracellular Delivery of Protein Drugs with Smart EnteroPatho Nanoparticles.
Ramirez-Velez, I., Namjoshi, A. A., Effiong, U. M., NA Peppas, & Belardi, B. ACS nano. (2024).

Near-infrared light-responsive hydrogels for on-demand dual delivery of proangiogenic growth factors.
Nazemidashtarjandi, S., Larsen, B., Cheng, K., Faulkner, S., NA Peppas, Parekh, S. H., & Zoldan, J. Acta biomaterialia (2024).

Model-based modular hydrogel design.
Richbourg, N., Wechsler, M. E., Rodriguez-Cruz, J. J., NA Peppas. Nat. Rev. Bioengineering. (2024).

Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers.
Chapa-Villarreal, F. A., Stephens, M., Pavlicin, R., Beussman, M., NA Peppas. Adv. Drug Deliv. Rev. (2024).

Design of nanoparticle-based systems for the systemic delivery of chemotherapeutics: Alternative potential routes via sublingual and buccal administration for systemic drug delivery.
Bahrami, K., Lee, E., Morse, B., Lanier, O., Peppas NA. Drug Deliv. and Transl. Res. (2024)

Tuning the pH-Responsive Properties of (2-Diisopropylamino) Ethyl Methacrylate-Based Cationic Nanoparticles: Toward Enhanced Nanoparticle Stability and Cytocompatibility.
Shodeinde, A., Lanier, O.L., Nallaparaju, S., Lam, M., Savk, A., Peppas, NA. Biomedical Materials & Devices 2, (2024)

A highly tuneable inverse emulsion polymerization for the synthesis of stimuli-responsive nanoparticles for biomedical applications.
Murphy AC, Oldenkamp HF, Peppas NA. Biomater. Sci., (2024)

A bright future in medicine for chemical engineering.
Langer, R., Peppas, N.A. Nat Chem Eng 1, (2024).

Drug delivery methods for cancer immunotherapy.
Pérez-Herrero, E., Lanier, O.L., Krishnan, N. et al. Drug Deliv. and Transl. Res. 14, 30–61 (2024).

2023 Publications

PEGylated insulin loaded complexation hydrogels for protected oral delivery.
Coolich, M. K., Lanier, O. L., Cisneros, E., NA Peppas. J. Controlled Release. (2023).

Structurally decoupled stiffness and solute transport in multi-arm poly(ethylene glycol) hydrogels. Richbourg, N. R., NA Peppas. Biomaterials(2023).

Stimuli-responsive self-assembled polymer nanoparticles for the oral delivery of antibodies.
Miller, M. K., Chapa-Villarreal, F. A., Oldenkamp, H. F., Elder, M. G., Venkataraman, A. K., NA Peppas. J. Controlled Release. (2023).

Self-assembled block copolymer biomaterials for oral delivery of protein therapeutics.
FA Chapa-Villarreal, MK Miller, JJ Rodriguez-Cruz, D Pérez-Carlos, NA Peppas. Biomaterials. (2023).

siRNA delivery mediated by pH and redox responsive p(DEAEMA-co-HEMA-g-PEGMA) nanogels.
MK Notabi, EC Arnspang, NA Peppas, MØ Andersen. Journal of Drug Delivery Science and Technology (2023).

Targeted delivery methods for RNA interference are necessary to obtain a potential functional cure for HIV/AIDS.
Cisneros, E., Sherwani, N., Lanier, O. L., NA Peppas. Adv. Drug Deliv. Rev. (2023).

Design of Synthetic Hydrogel Compositions for Noncovalent Protein Recognition.
JR Clegg, NA Peppas. ACS Applied Materials & Interfaces (2023).

Two-phase matrices for the controlled release of therapeutic proteins.
David, M., R. Mohanty, A., NA Peppas. Journal of Materials Chemistry B (2023).

Solute diffusion and partitioning in multi-arm poly(ethylene glycol) hydrogels.
NR Richbourg, NA Peppas. Journal of Materials Chemistry B (2023).

2022 Publications

Hydrogel-guided strategies to stimulate an effective immune response for vaccine-based cancer immunotherapy.
L Lei, D Huang, H Gao, B He, J Cao, NA Peppas. Science Advances (2022).

Cross-evaluation of stiffness measurement methods for hydrogels.
NR Richbourg, MK Rausch, NA Peppas. Polymer (2022).

Immunotherapy approaches for hematological cancers.
OL Lanier, E Pérez-Herrero, AP D’Andrea, K Bahrami, E Lee, DM Ward,N Ayala-Suarez, SM Rodriguez-Mendez, NA Peppas. Iscience (2022).

Influence of extracellular cues of hydrogel biomaterials on stem cell fate.
H Barnett, M Shevchuk, NA Peppas, M Caldorera-Moore. Journal of Biomaterial Science, Polymer Edition (2022).

Macroencapsulation Devices for Cell Therapy.
W Liu, Y Wang, J Wang, OL Lanier, ME Wechsler, NA Peppas, Z Gu. Engineering (2022).

Recent Advances in Glucose Responsive Insulin Delivery Systems: Novel Hydrogels and Future Applications.
AR Mohanty, A Ravikumar, NA Peppas. Regenerative Biomaterials. (2022).

Overcoming barriers in non-viral gene delivery for neurological applications.
A Tasset, A Bellamkonda, W Wang, I Pyatnitskiy, D Ward, N Peppas, H Wang. Nanoscale. (2022).

2021 Publications

Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic.
S Jain, A Venkataraman, ME Wechsler, NA Peppas. Adv. Drug Deliv. Rev. (2021).

Advanced biomedical hydrogels: Molecular architectures and its impact on biomedical applications.
JT Peters, ME Wechsler, NA Peppas. Regenerative Biomaterials. (2021).

High-throughput FRAP analysis of solute diffusion in hydrogels.
NR Richbourg, NA Peppas. Macromolecules. (2021).

Epitope-imprinted polymers: Design principles of synthetic binding partners for natural biomacromolecules.
SPB Teixeira, RL Reis, NA Peppas, ME Gomes, RMA Domingues. Sci. Adv. (2021).

Electrostatic and covalent assemblies of anionic hydrogel-coated gold nanoshells for detection of dry eye biomarkers in human tears.
ME Wechsler, HKHJ Dang, SP Simmonds, K Bahrami, JM Wyse, SD Dahlhauser, JF Reuther, AN VandeWalle, EV Anslyn, NA Peppas. Nano Lett. (2021).

Solute transport dependence on 3D geometry of hydrogel networks.
NR Richbourg, A Ravikumar, NA Peppas. Macromol. Chem. Phys. (2021).

Lipid- and polymer-based nanoparticle systems for the delivery of CRISPR/Cas9.
B Ahok, NA Peppas, ME Wechsler. j. Drug Deliv. Sci. Technol. (2021).

Recent advancements in biosensing approaches for screening and diagnostic applications.
AC Murphy, ME Wechsler, NA Peppas. Curr. Opin. Biomed. (2021).

Innovations in biomaterial design toward successful RNA interference therapy for cancer treatment.
DM Ward, AB Shodeinde, NA Peppas. Adv. Healthcare Mater. (2021).

Cytocompatibility, membrane disruption, and siRNA delivery using environmentally responsive cationic nanogels.
DA Spencer, AB Shodeinde, DW Beckman, BC Luu, HR Hodges, NA Peppas. J. Controlled Release. (2021).

Miniaturized needle array-mediated drug delivery accelerates wound healing.
M Samandari, F Aghabaglou, K Nuutila, H Derakhshandeh, Y Zang, Y Endo, S Harris, L Barum, C Kreike-meier-Bower, E Arab-Tehrany, NA Peppas, I Sinha, A Tamayol. Adv. Healthcare Mater. (2021).

Precise control of synthetic hydrogel network structure via linear, independent synthesis-swelling relationships.
NR Richbourg, M Wancura, AE Gilchrist, S Toubbeh, BAC Harley, E Cosgriff-Hernandez, NA Peppas. Sci. Adv., 7, eabe3245 (2021).

A combination chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting.
Y He, L Lei, J Cao, Z Yang, S Cai, F Tong, D Huang, H Mei, K Luo, H Gao, B He, NA Peppas, Sci. Adv., 7, eaba0776 (2021).

Epitope-imprinted nanoparticles as transforming growth factor-β3 sequestering ligands to modulate stem cell fate.
SPB Teixeira, RMA Domingues, PS Babo, D Berdecka, MS Miranda, ME Gomes, NA Peppas, RL Reis. Adv. Funct. Mater., 31, 2003934 (2021).

2020 Publications

Engineering precision nanoparticles for drug delivery.
MJ Mitchell, Mm Billingsley, RM Haley, ME Wechsler, NA Peppas, R Langer. Nat. Rev. Drug Discov., 20, 101-124 (2020).

Degradable PMMA-co-MAA nanoparticles for controlled delivery of growth factors for bone regeneration.
TM De Witte, AM Wagner, LE Fratila-Apachitei, AA Zadpoor, NA Peppas. Tiss. Eng. A., 26, 23-24, (2020).

Peptide conjugation enhances the cellular co-localization, but not endosomal escape, of modular poly(acrylamide-co-methacrylic acid) nanogels.
JR Clegg, JA Sun, J Gu, AK Venkataraman, NA Peppas. J. Controlled Release, 329 1162-1171 (2020).

Biodegradable cationic nanogels with tunable size, swelling and pKa for drug delivery.
DS. Spencer, AB Shodeinde, DW Beckman, BC Luu, HR Hodges, NA Peppas. Intern. J. Pharmaceutics, 588, 116691 (2020).

Biomaterials for sequestration of growth factors and modulation of cell behavior.
SPB Teixeira, RMA Domingues, M Shevchuk, ME Gomes, NA Peppas, RL Reis. Adv Functional Mater., (2020).

A tumor-to-lymph procedure navigated versatile gel system for combinatorial therapy against tumor recurrence and metastasis.
L Qin, J Cao, K Shao, F Tong, Z Yang, T Lei, Y Wang, C Hu, CS Umeshappa, H Gao, NA Peppas. Sci Adv 6, eabb3116 (2020).

Recent advances in smart biomaterials for the detection and treatment of autoimmune diseases.
A. Shodeinde, AC Murphy, HF Oldenkamp, AS Potdar, CM Ludolph, NA Peppas. Adv Functional Mater., 1909556 (2020).

Cell-laden alginate hydrogels for the treatment of diabetes.
L Izeia, T Eufrasio-da-Silva, A Dolatshahi-Pirouz, S Ostrovidov, G Paolone, NA Peppas, P De Vos, D Emerich, G Orive. Exp Opin in Drug Deliv., 17, 113-118 (2020).

CRISPR/Cas systems to overcome challenges in developing the next generation of T cells for cancer therapy.
D Huang, M Miller, B Ashok, S Jain, NA Peppas. Adv. Drug Deliv. Rev., 158, 17-35 (2020).

Effect of network mesh size and swelling to the drug delivery from pH responsive hydrogels.
RA Hegab, S Pardue, X Shen, C Kevil, NA Peppas, ME Caldorera‐Moore. J. Appl. Polym. Sci., 137, 48767 (2020).

QCM-D assay for quantifying the swelling, biodegradation, and protein adsorption of intelligent nanogels.
JR Clegg, CM Ludolph, NA Peppas. J. Appl. Polym. Sci., 137, 48655 (2020).

Advanced engineering nanoparticulate platforms to address key biological barriers for delivering chemotherapeutic agents to target sites.
J Cao, D Huang, NA Peppas. Adv. Drug. Deliv. Rev., 167, 170-188 (2020).

Developing a multidisciplinary approach for engineering stem cell organoids.
ME Wechsler, M Shevchuk, NA Peppas. Ann. Biomed. Eng., 48, 1895-1904 (2020).

The swollen polymer network hypothesis: Quantitative models of hydrogel swelling, mechanics, and solute transport.
NR Richbourg, NA Peppas. Prog. Poly. Sci., 105, 101243 (2020).

Immobilization of nanocarriers within a porous chitosan scaffold for the sustained delivery of growth factors in bone tissue engineering applications.
TM De Witte, AM Wagner, LE Fratila‐Apachitei, AA Zadpoor, NA Peppas. J. Biomed. Mater. Res., 108, 1122-1135 (2020).

Optimization of cationic nanogel PEGylation to achieve mammalian cytocompatibility with limited loss of gram-negative bactericidal activity.
J Gu, JR Clegg, LA Heersema, NA Peppas, HDC Smyth. Biomacromolecules 21, 1528-1538 (2020).

Polymer composition primarily determines the protein recognition characteristics of molecularly imprinted hydrogels.
Ak Venkataraman, JR Clegg, NA Peppas. J. Mater. Chem. B, 8, 7685-7695 (2020).

Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer-protein interactions.
ME Wechsler, HKHJ Dang, SD Dahlhauser, SP Simmonds, JF Reuther, JM Wyse, AN VandeWalle, EV Anslyn, NA Peppas. Chem. Comm., 56, 6141-6144 (2020).

Where physics meets chemistry meets biology for fundamental soft matter research.
JR Clegg, NA Peppas, V Palacio-Betancur, JC Armas-Pérez, S Villada-Gil, NL Abbott, JP Hernández-Ortiz, JJ de Pablo. Soft Matter. 16, 847-855 (2020).

Molecular recognition with soft biomaterials.
JR Clegg, NA Peppas. Soft Matter, 16, 856-869 (2020).